Listen to Base by Base podcast

405: PRDM9 and the Hotspot Trade-off	Base by Base	23:33
404: RUNA Reveals Surface DNA on Exosomes	Base by Base	21:02
403: HRD-GIS Evidence for BRCA1/2 Variant Classification	Base by Base	22:51
402: When Polygenic Scores Miss: Rare Variants in Misaligned Individuals	Base by Base	20:26
401: LDB1 variants split neurodevelopmental outcomes by location and mechanism	Base by Base	24:28
400: Complete chromosome 21 centromere sequencing and Down syndrome	Base by Base	22:30
399: Ménière disease: inner ear development and retinoic acid pathways	Base by Base	21:44
398: Modeling JAK2V617F Clonal Expansion in the General Population	Base by Base	24:52
397: SciPhy: Bayesian phylogenetics for sequential genetic lineage tracing	Base by Base	23:27
396: Physical homology recognition between DNA duplexes	Base by Base	23:26
395: Extended sequence context shapes mutational bias in Escherichia coli	Base by Base	22:43
394: Benchmarking LLMs for cfRNA biomarker discovery	Base by Base	22:34
393: Hidden Resistance: tNGS Reveals Rifampicin and Bedaquiline Resistance in Eswatini	Base by Base	21:20
392: GWAS of Cocaine Self-Administration in Heterogeneous Stock Rats	Base by Base	23:23
391: The Kaufmann Protocol — Why We Age and How to Stop It	Base by Base	66:28
390: Daunorubicin, Mutual Destruction, and Layered Antiphage Defense	Base by Base	22:59
389: Crotonylation impedes c-Myc oncogenic activity	Base by Base	25:28
388: Base by Base \| Episode 388 — In situ CAR‑macrophage alleviates liver fibrosis	Base by Base	21:01
387: Homotypic Dengue Reinfections and Long-Term Antibody Decay	Base by Base	21:36
386: Genome Doubling and the Bioeconomy	Base by Base	24:26
385: Growth under Pressure: Polyploidy Induced by Stress	Base by Base	24:49
384: RNA Brake on Cholera Phage: CisR Controls CTXϕ	Base by Base	23:10
383: Genetics of the Circulating Proteome: pQTLs, Pathways, and Disease Links	Base by Base	23:10
382: How animal blood cells evolved from unicellular ancestors	Base by Base	26:12
381: Light-written spatial barcodes enable tunable multiomic sequencing (BALI)	Base by Base	26:00
380: Prime-SGE maps drug-resistance variants at scale	Base by Base	11:38
379: Long reads reveal hidden structural and repeat variation in autism	Base by Base	26:30
378: Dominant-negative PSMB8 variants stall immunoproteasome assembly	Base by Base	23:06
377: ProteomeLM — proteome-scale language modeling for interactomes and essential genes	Base by Base	26:09
376: Pfh1's Balancing Act: Unwinding, Rewinding, and the Role of Mitochondrial SSB	Base by Base	27:53
375: Biallelic DSCAM LoF: a syndromic NDD with nystagmus and cone-pathway retinal dysfunction	Base by Base	22:45
374: DNA-guided Cas12a reprogrammed to target RNA	Base by Base	20:39
373: Base by Base 373 — A ciliate rewrites UAA and UAG	Base by Base	21:44
372: Genes, IQ and Socioeconomic Outcomes in Emerging Adults	Base by Base	24:42
371: Glial epigenomic dysregulation and genetic risk in tauopathies	Base by Base	26:06
370: ICMT and INPP5E enable BRAFV600E tumor growth	Base by Base	23:18
369: NEK2 drives EBV-positive NHL pathogenesis	Base by Base	24:30
368: PARP1 and Amyloid: Protecting Neurons in a Familial AD Model	Base by Base	26:43
367: Ancestral Splice Variation Fuels Cichlid Jaw Diversification	Base by Base	22:53
366: BRCA1P1 suppresses antiviral and antitumor immunity	Base by Base	24:15

405: PRDM9 and the Hotspot Trade-off

Base by Base

23:33

404: RUNA Reveals Surface DNA on Exosomes

Base by Base

21:02

403: HRD-GIS Evidence for BRCA1/2 Variant Classification

Base by Base

22:51

402: When Polygenic Scores Miss: Rare Variants in Misaligned Individuals

Base by Base

20:26